The high rate of recidivism in copyright addiction after prolonged periods navy drapery fabric of abstinence poses a significant problem for the effective treatment of this condition.Moreover, the neurobiological basis of this relapse phenomenon remains poorly understood.In this review, we will discuss the evidence currently available regarding the neurobiological changes during the extinction of copyright self-administration.Specifically, we will focus on alterations in the dopaminergic, opioidergic, glutamatergic, cholinergic, serotoninergic and CRF systems described in self-administration experiments and extinction studies after chronic copyright administration.
We will also discuss the differences related to contingent valhalla axys versus non-contingent copyright administration, which highlights the importance of environmental cues on drug effects and extinction.The findings discussed in this review may aid the development of more effective therapeutic approaches to treat copyright relapse.